High-Purity Silybin (Silibinin) Powder Isolate 95% 98% | Standardized Milk Thistle Seed Extract

Other Name	Silybin (Silibinin)
Appearance	Off-white to Pale Yellow Powder
Specifications	95% , 98%
Price	100-500 USD
MOQ	1KG
Application	Health care
Certificates	HACCP, ISO22000, Kosher, Halal, TÜVRheinland, EU Organic Certificate, USDA, NOP, FDA

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product details

Silybin (Silibinin)

High-Purity Botanical Extract | HPLC 95% & 98% Grade

Silybin is the primary active isomer of Silymarin, recognized globally for its superior hepatoprotective and antioxidant properties. By isolating Silybin at 95% and 98% purity, we provide formulators with a highly concentrated, crystalline raw material that ensures batch-to-batch consistency for premium dietary supplements and pharmacological research.

Pharmaceutical Grade Foundation: Derived from premium Silybum marianum seeds.

Precision Assay Control: Standardized to ≥95.0% and ≥98.0% by HPLC.

Verified Safety: Food-grade ethanol extraction, compliant with USP/EP standards.

Technical Specifications

Comprehensive Quality Control Parameters

Product Name	Silybin (Silibinin)
Botanical Source	Silybum marianum (L.) Gaertn.
Part Used	Seed
Specification	HPLC 95% / HPLC 98%
Appearance	Light yellow to white powder
Character	Odorless, slightly bitter taste
Solubility	Soluble in Acetone, Ethyl Acetate, Methanol, Ethanol; Sparingly soluble in Chloroform; Practically insoluble in Water.
Shelf Life	24 Months (Properly Stored)
Storage Conditions	Store in a cool, dry, and dark place. Keep container tightly closed when not in use.

Quality Distinction

The Standard of High-Purity Silybin

Premium Isolate

Silybin Isolate (95%/98%)

✔ Visual Grade: Crystalline white to off-white powder, indicating meticulous purification.
✔ Solvent Profile: Processed exclusively with food-grade Ethanol; compliant with USP/EP standards.
✔ Application Specificity: Pure flavonolignan monomer ideal for pharmaceutical R&D and targeted formulations.

Standard Extract

✘ Appearance: Brownish-yellow powder containing non-active plant lipids and pigments.
✘ Solvent Methods: Potential use of various industrial solvents to maintain lower cost structures.
✘ Composition: A complex mixture of isomers with lower concentration of the primary bioactive.

Technical Note: As the primary bioactive flavonolignan derived from Silybum marianum, Silybin is the most clinically researched isomer within the Silymarin complex. Our 98% grade offers the maximum concentration of this bioactive monomer, specifically refined to support antioxidant defense in hepatic cells and ensure superior batch-to-batch consistency.

Manufacturing Process

Traceable, All-Ethanol Purification Pathway

Seed Selection

Premium seeds, Identity testing, High flavonolignans.

Solvent Extraction

100% Food-grade Ethanol, No methanol/acetone.

Isolation

Enriched silymarin, Inert material removed.

Precision Purification

Chromatography + Recrystallization, Separates Isomers.

Crystalline Isolate

HPLC ≥95%/98%, White powder, Customized mesh.

Certificate of Analysis

Product Name	Silybin (Silibinin)	Quantity	1000 kg
Batch No.	CRSL260328	Test Date	2026-03-29
Manufacturing Date	2026-03-28	Expiry Date	2028-03-27
Items	Specification	Methods	Results
Color	White	GB1886.244-2016	Conformity
Form	Powder	GB1886.244-2016	Conformity
Assay	≥98%	GB1886.244-2016	98.62%
Loss on Drying (g/100g)	≤5.0	GB1886.244-2016	1.94
Ash content（%）	≤4.0	GB1886.244-2016	0.10
Arsenic (as As) (mg/kg)	≤2.0	GB1886.244-2016	Conformity
Lead (as Pb) (mg/kg)	≤5.0	GB1886.244-2016	Conformity
Shelf Life	24 months under the conditions below, no antioxidant used
Package	25 kg/carton outside and double food plastic bags inside.
Storage	Store in a cool, dry place away from Moisture, Light, Oxygen

Biological Functions

Core Mechanisms of High-Purity Silybin

01.

Liver Cell Protection

Stabilizes hepatocyte membranes and inhibits lipid peroxidation.

02.

Potent Antioxidant

Directly scavenges free radicals; significantly stronger than standard silymarin extract.

03.

Anti-inflammatory

Suppresses NF-κB pathway and reduces pro-inflammatory cytokines.

04.

Anti-fibrotic

Inhibits hepatic stellate cell activation, supporting liver tissue integrity.

05.

Bile Flow Support

Promotes bile secretion for healthy liver-gallbladder function.

Coleus Forskohlii Extract Application01 (2)

Industrial Applications

Precision Solutions for High-End Markets

Liver Support Supplements

95%/98% silybin for high-dose, precision-label capsule and tablet formulations.

Pharmaceutical Intermediate

API-grade material specifically refined for professional liver-protective drug development.

Combination Formulas

Perfectly pairs with NAC, Phosphatidylcholine, or Vitamin E for premium multi-ingredient products.

Veterinary Liver Health

Targeting EU and North American companion animal markets for premium liver support.

Cosmetics & Topical

INCI compliant antioxidant active designed for premium anti-aging skincare.

Frequently Asked Questions

Quick Technical Answers for Professionals

Q1:

How is your 95%/98% Silybin different from standard 80% Silymarin?

Standard silymarin contains only ~30% silybin — the rest is a mixture of inactive or lower-activity flavonolignans (isosilybin, silychristin, silydianin). Our isolate delivers silybin as the dominant active ingredient at ≥95%/98%, enabling precise dosing, stronger antioxidant activity per gram, and clean label claims for your finished product.

Q2:

What extraction solvent do you use, and are there residual solvent concerns?

We use 100% food-grade ethanol throughout the entire process — no methanol, no acetone, no ethyl acetate. Residual solvent levels in the final product comply with ICH Q3C Class 3 limits, and a GC headspace test result is included in every batch Certificate of Analysis (CoA).

Q3:

Is this material suitable for phytosome manufacturing?

Yes. High-purity free silybin is the standard upstream raw material for silybin-phosphatidylcholine complex (phytosome) synthesis — the form with significantly enhanced oral bioavailability. We can also supply documentation supporting downstream phosphatidylcholine complex formulation if needed.

Professional Supply Chain & Services

Quality Certifications

Verified Organic, ISO, and Non-GMO standards for global compliance.

Custom OEM/ODM

Tailored formulation and branding solutions for your private label.

Secure Packaging

Professional grade multi-layer protection for long-distance transit.

Fast Global Delivery

Efficient logistics network providing reliable air and sea shipping.

Private Label and Customized Service

Silybin (Silibinin) Powder is wholesale at the absolutely competitive price for business, and you can also get OEM packaging and private label service from us, so that you can retail the Silybin (Silibinin) Powder in small package with your logo and design. Furthermore, Silybin (Silibinin) Powder can be supplied in powder and tablet form.

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