High-Purity Silybin (Silibinin) Powder Isolate 95% 98% | Standardized Milk Thistle Seed Extract
Technical Specifications
Comprehensive Quality Control Parameters
| Product Name | Silybin (Silibinin) |
| Botanical Source | Silybum marianum (L.) Gaertn. |
| Part Used | Seed |
| Specification | HPLC 95% / HPLC 98% |
| Appearance | Light yellow to white powder |
| Character | Odorless, slightly bitter taste |
| Solubility | Soluble in Acetone, Ethyl Acetate, Methanol, Ethanol; Sparingly soluble in Chloroform; Practically insoluble in Water. |
| Shelf Life | 24 Months (Properly Stored) |
| Storage Conditions | Store in a cool, dry, and dark place. Keep container tightly closed when not in use. |
Quality Distinction
The Standard of High-Purity Silybin
Silybin Isolate (95%/98%)
- ✔ Visual Grade: Crystalline white to off-white powder, indicating meticulous purification.
- ✔ Solvent Profile: Processed exclusively with food-grade Ethanol; compliant with USP/EP standards.
- ✔ Application Specificity: Pure flavonolignan monomer ideal for pharmaceutical R&D and targeted formulations.
Standard Extract
- ✘ Appearance: Brownish-yellow powder containing non-active plant lipids and pigments.
- ✘ Solvent Methods: Potential use of various industrial solvents to maintain lower cost structures.
- ✘ Composition: A complex mixture of isomers with lower concentration of the primary bioactive.
Technical Note: As the primary bioactive flavonolignan derived from Silybum marianum, Silybin is the most clinically researched isomer within the Silymarin complex. Our 98% grade offers the maximum concentration of this bioactive monomer, specifically refined to support antioxidant defense in hepatic cells and ensure superior batch-to-batch consistency.
Manufacturing Process
Traceable, All-Ethanol Purification Pathway
Seed Selection
Premium seeds, Identity testing, High flavonolignans.
Solvent Extraction
100% Food-grade Ethanol, No methanol/acetone.
Isolation
Enriched silymarin, Inert material removed.
Precision Purification
Chromatography + Recrystallization, Separates Isomers.
Crystalline Isolate
HPLC ≥95%/98%, White powder, Customized mesh.
Certificate of Analysis
|
Product Name |
Silybin (Silibinin) |
Quantity |
1000 kg |
|
Batch No. |
CRSL260328 |
Test Date |
2026-03-29 |
|
Manufacturing Date |
2026-03-28 |
Expiry Date |
2028-03-27 |
|
Items |
Specification |
Methods |
Results |
|
Color |
White |
GB1886.244-2016 |
Conformity |
|
Form |
Powder |
GB1886.244-2016 |
Conformity |
|
Assay |
≥98% |
GB1886.244-2016 |
98.62% |
|
Loss on Drying (g/100g) |
≤5.0 |
GB1886.244-2016 |
1.94 |
|
Ash content（%） |
≤4.0 |
GB1886.244-2016 |
0.10 |
|
Arsenic (as As) (mg/kg) |
≤2.0 |
GB1886.244-2016 |
Conformity |
|
Lead (as Pb) (mg/kg) |
≤5.0 |
GB1886.244-2016 |
Conformity |
|
Shelf Life |
24 months under the conditions below, no antioxidant used |
||
|
Package |
25 kg/carton outside and double food plastic bags inside. |
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|
Storage |
Store in a cool, dry place away from Moisture, Light, Oxygen |
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Industrial Applications
Precision Solutions for High-End Markets
Liver Support Supplements
95%/98% silybin for high-dose, precision-label capsule and tablet formulations.
Pharmaceutical Intermediate
API-grade material specifically refined for professional liver-protective drug development.
Combination Formulas
Perfectly pairs with NAC, Phosphatidylcholine, or Vitamin E for premium multi-ingredient products.
Veterinary Liver Health
Targeting EU and North American companion animal markets for premium liver support.
Cosmetics & Topical
INCI compliant antioxidant active designed for premium anti-aging skincare.
Frequently Asked Questions
Quick Technical Answers for Professionals
How is your 95%/98% Silybin different from standard 80% Silymarin?
Standard silymarin contains only ~30% silybin — the rest is a mixture of inactive or lower-activity flavonolignans (isosilybin, silychristin, silydianin). Our isolate delivers silybin as the dominant active ingredient at ≥95%/98%, enabling precise dosing, stronger antioxidant activity per gram, and clean label claims for your finished product.
What extraction solvent do you use, and are there residual solvent concerns?
We use 100% food-grade ethanol throughout the entire process — no methanol, no acetone, no ethyl acetate. Residual solvent levels in the final product comply with ICH Q3C Class 3 limits, and a GC headspace test result is included in every batch Certificate of Analysis (CoA).
Is this material suitable for phytosome manufacturing?
Yes. High-purity free silybin is the standard upstream raw material for silybin-phosphatidylcholine complex (phytosome) synthesis — the form with significantly enhanced oral bioavailability. We can also supply documentation supporting downstream phosphatidylcholine complex formulation if needed.
