High Purity Liquiritin Powder 98% CAS 551-15-5 Licorice Root Extract Bulk Supply OEM GMP Factory Direct
High Purity Liquiritin Powder 98%
Liquiritin Powder 98% is a high-purity flavanone glycoside extracted from the root of Glycyrrhiza uralensis Fisch. As one of the principal flavonoids in licorice root, liquiritin has been extensively studied for its tyrosinase-inhibiting, antioxidant, and anti-inflammatory properties. Manufactured under GMP conditions with HPLC-verified batch consistency. Annual capacity 50+ MT, vertically integrated supply chain, custom OEM packaging available.
Specifications
Certification Matrix
Product Highlights
Annual Capacity 50+ MT
Over 50 metric tons annual production capacity. GMP facility with continuous extraction lines, batch-to-batch HPLC consistency at ≥98%.
Vertically Integrated
From contracted cultivation to finished powder. No third-party intermediaries, no quality blind spots. Full chain traceability.
Full Documentation
Batch-specific COA with HPLC assay, heavy metals, microbiology. MSDS, TDS, and organic certification available on request.
Custom OEM/ODM
Formulation blending, capsule/tablet manufacturing, private-label packaging. From pilot to commercial scale.
Certificate of Analysis (COA)
| Product Name | Liquiritin Powder | Batch No. | CRS260716 |
| CAS No. | 551-15-5 | Test Date | 2026-07-16 |
| Manufacturing Date | 2026-07-10 | Expiry Date | Refer to batch COA |
| Items | Specification | Methods | Results |
| Assay (Liquiritin) | ≥98% | HPLC | 98.6% |
| Appearance | White to Light Yellow Powder | Visual | Conforms |
| Melting Point | 210-213°C | DSC | 211.8°C |
| Loss on Drying | ≤1.0% | Gravimetric | 0.48% |
| Residue on Ignition | ≤0.5% | Gravimetric | 0.12% |
| Heavy Metals (as Pb) | ≤10 ppm | ICP-MS | Conforms |
| Arsenic (As) | ≤1 ppm | ICP-MS | Conforms |
| Cadmium (Cd) | ≤1 ppm | ICP-MS | Conforms |
| Mercury (Hg) | ≤0.1 ppm | ICP-MS | Conforms |
| Microbial - TPC | ≤1,000 CFU/g | Plate Count | Conforms |
| Yeast & Mold | ≤100 CFU/g | Plate Count | Conforms |
| E. coli | Negative / 25g | USP <62> | Conforms |
| Salmonella | Negative / 25g | USP <62> | Conforms |
| Shelf Life | Please refer to the batch-specific COA and product labelling for the exact expiry date. | ||
| Package | 1 kg/foil bag or 25 kg/drum; nitrogen flushing and light protection included. | ||
| Storage | Store at 2-8°C in a cool, dry, dark, and sealed container. | ||
Function & Mechanism
Tyrosinase Inhibition
Competitive inhibitor of tyrosinase, the rate-limiting enzyme in melanin biosynthesis. Reduces L-DOPA oxidation with measurable IC50 values. Batch consistency verified through HPLC purity profiling.
Antioxidant Activity
4',7-dihydroxyflavanone backbone donates hydrogen to neutralize ROS. Dual electron-donating sites enable effective DPPH and ABTS radical scavenging, standardized through HPLC-verified purity.
Anti-Inflammatory Pathway
Suppresses NF-κB nuclear translocation and downregulates COX-2 expression. Reduces PGE2 production and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β).
Hepatoprotective Activity
Stabilizes hepatocyte membranes and reduces serum ALT/AST under oxidative stress. Glycoside structure enables hepatic uptake and conversion to aglycone (liquiritigenin).
Applications
Cosmetic Manufacturing
Primary active for skin-brightening formulations at 0.5-2.0% inclusion. Tyrosinase inhibitor in serums, creams, and masks. Compatible with O/W and W/O emulsion systems. pH 5.0-7.0.
Nutraceutical Formulation
Antioxidant and hepatoprotective properties for dietary supplements. Bulk powder for capsule filling, tablet compression, or liquid extract blending. Standardized to 98% HPLC.
Food & Beverage Additive
Natural flavor enhancer and sweetener (100-500x sucrose). Suitable for combination with other natural sweeteners in reduced-sugar product development.
