High Purity Glycyrrhetinic Acid 98% Powder CAS 471-53-4 Bulk Supply OEM GMP Factory Direct Wholesale
Glycyrrhetinic Acid 98%
Glycyrrhetinic Acid Powder standardized to 98% purity — the active aglycone derived from Glycyrrhiza uralensis Fisch root, delivering superior bioavailability and 3-5x the anti-inflammatory potency of glycyrrhizic acid. Manufactured in GMP-compliant facilities with full traceability from plantation to powder. Every batch verified by HPLC with complete COA documentation. Backed by ISO22000, HACCP, TUV Rheinland, EU Organic, USDA NOP, Kosher, and Halal certifications. Engineered for pharmaceutical intermediates, high-performance cosmeceuticals, and industrial-scale skincare formulations. Available from 1 KG MOQ with OEM tablet compression, capsule filling, and private labeling.
Specifications
Botanical Sourcing & Supply Chain
Glycyrrhiza uralensis Fisch — Chinese licorice — cultivated across northern China semi-arid growing zones, where mineral-rich alkaline soils and continental climate drive consistent triterpenoid accumulation in root tissues. Our supply chain is vertically integrated: contracted cultivation bases feed directly into in-house hydrolysis and purification facilities.
The production pathway follows a two-stage process: first, glycyrrhizic acid is extracted from 3-4 year mature roots via water-based extraction; second, controlled acid hydrolysis cleaves the glycosidic bonds to release the aglycone — 18 Beta-glycyrrhetinic acid. Subsequent membrane separation and recrystallization achieve 98% purity. Each production batch is traceable to its harvest lot, with retained samples archived for 24 months.
Product Highlights
Aglycone Advantage — 3-5x Potency
As the hydrolysis-derived aglycone of glycyrrhizic acid, glycyrrhetinic acid delivers approximately 3-5 times the anti-inflammatory potency of its parent glycoside. For formulators, this means lower inclusion rates, reduced raw material cost per active unit, and more compact dosage forms.
Multi-Certification Platform
Triple-certified manufacturing (ISO22000 + HACCP + TUV Rheinland) backed by dual organic certifications (EU Organic & USDA NOP) and religious certifications (Kosher, Halal). FDA-registered facility covers regulatory requirements across North America, Europe, Middle East, and Asia-Pacific.
HPLC-Verified 98% with Full COA
Every production batch undergoes HPLC quantification against certified 18 Beta-glycyrrhetinic acid reference standards. Full COA issued with each shipment including purity, melting point, heavy metals, residual solvents, chloride, and sulfate analysis.
Flexible OEM — Powder to Dosage
Custom particle sizing (80-200 mesh), branded packaging (1kg pouch to 25kg fiber drum), and downstream OEM services including tablet compression and capsule filling. Bulk pricing from $60/kg at scale with predictable lead times.
Certificate of Analysis (COA)
| Product Name | Glycyrrhetinic Acid Powder | Batch No. | CRS20260610 |
| CAS No. | 471-53-4 | Test Date | 2026-06-11 |
| MFG Date | 2026-06-10 | Expiry Date | 2028-06-09 |
| Items | Specification | Methods | Results |
| Assay (HPLC) | ≥ 98% | HPLC | 98.5% |
| Appearance | White to Off-White Crystalline Powder | Visual | Conforms |
| Loss on Drying | ≤ 1.0% | Gravimetric | 0.6% |
| Residue on Ignition | ≤ 0.5% | Gravimetric | 0.18% |
| Melting Point | 292-298 Deg C | Capillary | 295.2 Deg C |
| Heavy Metals | ≤ 10 ppm | ICP-MS | Conforms |
| Lead (Pb) | ≤ 2.0 mg/kg | ICP-MS | Conforms |
| Cadmium (Cd) | ≤ 2.0 mg/kg | ICP-MS | Conforms |
| Arsenic (As) | ≤ 1.0 mg/kg | ICP-MS | Conforms |
| Mercury (Hg) | ≤ 0.1 mg/kg | ICP-MS | Conforms |
| Total Plate Count | ≤ 1000 cfu/g | Plate Count | Conforms |
| Yeast & Mold | ≤ 100 cfu/g | Plate Count | Conforms |
| E. coli | Negative / 25g | USP <62> | Conforms |
| Salmonella | Negative / 25g | USP <62> | Conforms |
| Shelf Life | Please refer to the batch-specific COA and product labelling for the exact expiry date. | ||
| Storage | Store in a cool, dry, dark, and sealed container below 25 Deg C. | ||
Function & Biochemical Mechanisms
PLA2 & COX-2 Dual-Pathway Anti-Inflammatory
Demonstrates well-characterized inhibition of phospholipase A2 (PLA2) — the upstream rate-limiting enzyme in the arachidonic acid cascade — as well as cyclooxygenase-2 (COX-2). This dual-pathway mechanism blocks pro-inflammatory mediator production at two distinct enzymatic nodes, providing a standardized anti-inflammatory active backbone for pharmaceutical intermediates. HPLC-verified 98% purity ensures reproducible bioactivity dose-to-dose.
Ceramide Synthesis Upregulation — Barrier Quantification
Upregulates epidermal ceramide synthesis and strengthens tight junction protein expression, quantifiably reducing transepidermal water loss (TEWL). For cosmetic and cosmeceutical manufacturers, this translates to a bioactive ingredient with measurable barrier-repair endpoints — directly supporting clinical efficacy claims for sensitive-skin and post-procedure recovery formulations.
Free Radical Scavenging — UVB Damage Mitigation
In vitro and ex vivo studies document the capacity to scavenge UVB-induced reactive oxygen species (ROS) and preserve endogenous antioxidant enzyme activity (SOD, CAT, GSH-Px). Combined with anti-inflammatory mechanism, positions it as a dual-function active for anti-aging cosmeceuticals targeting photoaging pathways.
Mast Cell Stabilization — Histamine Suppression
Inhibits IgE-dependent mast cell degranulation and histamine release — a quantifiable anti-allergic mechanism. For topical pharmaceutical manufacturers, this supports development of OTC anti-itch, anti-eczema, and anti-dermatitis formulations with a well-characterized botanical active ingredient.
Hepatic Cytoprotection — ALT/AST Normalization
Preclinical models demonstrate hepatoprotective effects via reduction of serum ALT and AST levels and attenuation of TNF-alpha-mediated hepatocellular apoptosis. Supports nutraceutical liver-health formulation development with a dose-standardized botanical active.
Applications
Pharmaceutical Intermediates & Topical Formulations
Standardized botanical anti-inflammatory active for topical corticosteroid adjuvants, anti-eczema ointments, anti-dermatitis creams, and oral mucosal protective formulations. Compatible with ointment, cream, gel, and oral dosage form manufacturing. 98% purity meets pharmaceutical intermediate specifications.
High-Performance Cosmeceutical Manufacturing
Anti-aging serums, barrier-repair creams, post-procedure recovery formulations, skin-brightening products. Fine powder (80 mesh) ensures homogeneous dispersion in both oil-phase and water-phase cosmetic manufacturing. Compatible with cold-process and hot-process methods.
Sensitive-Skin Personal Care Product Lines
Gentle cleansers, soothing toners, after-sun repair gels, anti-redness treatment products. Dual anti-inflammatory + barrier-repair mechanism allows formulators to build multi-benefit product narratives around a single active, reducing BOM complexity.
Nutraceutical & Dietary Supplement Manufacturing
Liver-health support, mucosal comfort, anti-inflammatory supplement formulations. Available as raw powder for blending, direct compression, or encapsulation. Custom particle sizing (80-200 mesh) supports diverse manufacturing processes.
