High Absorption Liposomal Urolithin A Powder 50% 70% CAS 1143-70-0 Bulk Supply OEM Factory Direct
Liposomal
Urolithin A
Liposomal Urolithin A Powder delivers 50% or 70% active Urolithin A (CAS 1143-70-0) — a dibenzopyranone metabolite known for activating mitochondrial quality-control pathways — encapsulated within phospholipid bilayer vesicles. Native UA has extremely low water solubility and is sensitive to oxidation at its phenolic hydroxyl groups, both limiting factors for conventional powder formats. Liposomal encapsulation embeds UA within the hydrophobic lipid core, creating a water-dispersible powder that addresses solubility and stability in a single manufacturing step. GMP-compliant facility with deep liposomal manufacturing experience.
TECHNICAL SPECIFICATIONS
LIPOSOMAL DELIVERY PRINCIPLE
Urolithin A is a dibenzopyranone — a planar aromatic molecule with hydroxyl groups at positions 3 and 8. This structure creates two manufacturing challenges: extremely low native water solubility (the flat aromatic core resists hydration), and oxidative sensitivity at the phenolic hydroxyl positions, which can lead to dimerization or degradation during storage. These directly affect content uniformity, dissolution behavior, and active-content retention in conventional powder formats.
Liposomal encapsulation provides three solutions: (1) the phospholipid bilayer embeds UA within its hydrophobic lipid interior, bypassing solubility limitations without organic co-solvents; (2) nano-scale vesicle architecture (80–300 nm, DLS-verified) creates a dispersible powder that forms stable suspensions in water; (3) EE% ≥ 80% via dialysis/HPLC on every batch — distinguishing genuine liposomal UA from simple dry blends of UA with phospholipids.
KEY ADVANTAGES
1. Dual Loading Strategy: 50% & 70%
50% is cost-optimized for multi-ingredient mitochondrial blends, pomegranate-centered complexes, and CoQ10 / PQQ combinations. 70% maximizes UA payload per gram, enabling compact high-potency capsules with fewer pills per serving. Both grades share identical manufacturing, QC, and CoA protocols.
2. Solubility Without Synthetic Surfactants
Native Urolithin A is virtually insoluble in water — a formulation bottleneck for liquid capsules and beverage powders. Liposomal encapsulation embeds UA in the hydrophobic core of phospholipid vesicles, creating a water-dispersible powder without organic co-solvents or synthetic surfactants.
3. Verified Encapsulation — Beyond Simple Blending
EE% ≥ 80% (dialysis/HPLC) distinguishes genuine liposomal UA from physical phospholipid blends. DLS particle sizing confirms consistent nano-scale vesicle dimensions. HPLC active assay verifies exact 50% or 70% loading. Heavy metal and microbial screening per shipment.
4. Multi-Format Production Compatibility
Free-flowing powder compatible with capsule filling, tablet compression, sachet filling, and stick-pack operations. Compatible with CoQ10, PQQ, B vitamins, amino acids, and botanical actives. 25 kg drums, 1 kg foil bags, and custom OEM packaging.
QUALITY VERIFICATION
1. HPLC Active Assay
Every batch tested to confirm 50% or 70% UA loading. Batch-specific CoA issued with each shipment.
2. EE% by Dialysis/HPLC
Encapsulation Efficiency ≥ 80% confirms genuine liposomal encapsulation — the analytical distinction between a liposomal product and a UA-phospholipid blend.
3. DLS Particle Size Analysis
Confirms stable liposome formation (80–300 nm) upon rehydration. Consistent nano-scale architecture is essential for reproducible dissolution and content uniformity.
4. Heavy Metal & Microbial Screening
Pb ≤ 10 ppm, As/Cd ≤ 1 ppm, Hg ≤ 0.1 ppm; TPC and Yeast & Mold per USP; E. coli and Salmonella negative per 25g. Third-party ISO 17025 lab testing available.
FUNCTIONAL ROLES
These statements describe established nutritional roles of Urolithin A using structure/function language. They have not been evaluated by regulatory authorities. This product is not intended to diagnose, treat, cure, or prevent any disease.
1. Mitochondrial Quality Control (Mitophagy)
Urolithin A activates cellular pathways that govern mitophagy — the selective removal and recycling of damaged mitochondria. This process is part of normal cellular maintenance and is essential for sustaining mitochondrial population quality — relevant for cellular health and metabolic wellness formulations.
2. Cellular Energy Metabolism Support
Mitochondria generate ATP through oxidative phosphorylation — the fundamental energy currency of the cell. By supporting mitochondrial quality, UA contributes to the cellular environment that enables efficient energy metabolism — positioning it for metabolic health formulations.
3. Muscle Cell Mitochondrial Health
Skeletal muscle is one of the most mitochondrially-dense tissues. UA's established role in mitophagy activation is relevant for formulations targeting muscle health, physical performance support, and active lifestyle product categories.
4. Nutrient Synergy & Co-Formulation
Urolithin A is commonly formulated alongside CoQ10 / ubiquinol, PQQ, and B vitamins. The liposomal format protects all co-formulated actives from mutual oxidative interactions during blending and storage — a practical advantage for multi-component manufacturers.
INDUSTRIAL APPLICATIONS
1. Mitochondrial Health Capsules
Urolithin A combined with CoQ10 / ubiquinol and PQQ. Liposomal encapsulation addresses UA's solubility limitation, ensuring uniform distribution in multi-component dry blends.
2. Cellular Health & Healthy Aging Formulations
UA's mitophagy-activation role positions it for premium cellular health products. The 70% grade enables compact, high-potency single-active capsules for informed consumers.
3. Muscle & Physical Performance Support
UA formulated with creatine, amino acids, and electrolytes for muscle health products. Free-flowing liposomal powder ensures homogeneous dry-blend distribution.
4. Pomegranate Botanical Complexes
UA combined with pomegranate extract and ellagic acid for products that tell a coherent botanical-to-bioactive narrative. The metabolite connection to pomegranate creates a differentiated brand story.
OEM & PACKING
OEM & CUSTOM FORMULATION
CERTIFICATIONS
TRANSPORTATION
PACKAGING
TECHNICAL FAQ
Urolithin A is a specific metabolite — not directly extracted from any plant source. In nature, it is produced when gut bacteria convert ellagic acid (from pomegranates, berries, walnuts) into UA. Our product contains synthetic Urolithin A (CAS 1143-70-0), chemically identical to this naturally-occurring metabolite. The phospholipids used for encapsulation are from non-GMO plant sources (sunflower or soy lecithin).
50% = 500 mg Urolithin A per gram of powder, suited for multi-ingredient blends. 70% = 700 mg per gram, suited for high-potency single-active products. All other specifications — EE%, particle size, PDI, QC protocols — are identical between grades. Choose based on your target dosage per capsule or serving.
EE% ≥ 80% by dialysis/HPLC confirms genuine encapsulation — distinguishing it from simple physical blends of UA and phospholipids. DLS particle sizing verifies consistent 80–300 nm vesicle dimensions. Both are measured per batch and documented on the CoA. Batch-specific HPLC assay confirms exact 50% or 70% UA loading.