High Absorption Liposomal Spermidine Powder 50% 70% CAS 124-20-9 Bulk Supply OEM GMP Factory Direct
LIPOSOMAL
SPERMIDINE POWDER
50% | 70%
Liposomal Spermidine Powder delivers 50% or 70% active spermidine (CAS 124-20-9) — a naturally occurring polyamine from wheat germ and soybeans — encapsulated within a phospholipid bilayer via industrial emulsification and spray-drying. A scalable, dual-strength B2B ingredient positioned for the growing cellular wellness supplement market.
TECHNICAL SPECIFICATIONS
LIPOSOMAL DELIVERY PRINCIPLE
Spermidine is a polyamine — a naturally occurring organic cation with multiple amine groups. It faces two industrial formulation challenges: susceptibility to ambient oxidation and rapid non-selective dispersion in powder blends, creating potential homogeneity issues in multi-component formulations.
Our liposomal process addresses both. Spermidine is co-dissolved with phospholipids, emulsified under controlled high-shear conditions, and spray-dried. Key production benefits: (1) oxidative protection — the bilayer shields spermidine from ambient oxygen during storage and blending; (2) controlled dispersion — the carrier moderates release profile and reduces segregation; (3) enhanced matrix compatibility — uniform integration with other active ingredients in complex multi-component blends.
KEY ADVANTAGES
1. Dual-Strength Manufacturing
Two standardized loadings — 50% for mainstream pricing and 70% for premium high-potency lines — served from a single production platform. Match your market positioning without changing suppliers.
2. Industrial Batch Consistency
Tight EE% (≥80%) and PDI (≤0.35) monitoring ensures uniform spermidine loading and particle characteristics across every shipment. HPLC assay verification accompanies each batch.
3. Oxidative Stability for Blending
Unlike unencapsulated spermidine susceptible to ambient oxidation during extended blending, the liposomal carrier provides a protective lipid microenvironment — a practical benefit for manufacturers managing multi-ton annual volumes.
4. Multi-Format Versatility
Compatible with capsule filling (00–3 sizes), direct-compression tablets, stick-pack blends, and functional beverage premixes — one ingredient across multiple finished-product SKUs.
MANUFACTURING PROCESS
Raw Material Qualification
Spermidine active (HPLC-verified, ≥98% purity) and plant-derived phospholipids are identity-tested. Each lot screened against specification before production release.
Lipid-Phase Preparation & Emulsification
Spermidine co-dissolved with phospholipids under controlled temperature, then precision high-shear emulsified into aqueous phase — forming stable nano-emulsion with spermidine entrapped within bilayer vesicles.
Spray-Drying
Emulsion spray-dried under optimized temperature profiles, converting liquid liposomal suspension into dry, free-flowing powder while preserving vesicle integrity.
QC Release & CoA
HPLC assay, DLS particle sizing, EE% measurement, heavy metal screening, and microbial testing completed before batch release. Batch-specific CoA issued with every shipment.
CERTIFICATE OF ANALYSIS (COA)
| Product Name | Liposomal Spermidine Powder | Batch No. | CRS20260608 |
| CAS No. | 124-20-9 | Test Date | 2026-06-09 |
| Mfg. Date | 2026-06-08 | Expiry Date | 2026-06-07 |
| Items | Specification | Methods | Results |
| Assay (Spermidine) | 50% / 70% | HPLC | 50.2% / 70.1% |
| Encapsulation Efficiency | ≥ 80% | Centrifugation-UV | 83.0% |
| Particle Size | 80–300nm | DLS | 195nm |
| PDI | ≤ 0.35 | DLS | 0.27 |
| Appearance | White to Off-White Powder | Visual | Conformity |
| Loss on Drying | ≤ 5.0% | Gravimetric | 3.5% |
| Heavy Metals (as Pb) | ≤ 10 ppm | ICP-MS | Conformity |
| Arsenic (As) | ≤ 1 ppm | ICP-MS | Conformity |
| Cadmium (Cd) | ≤ 1 ppm | ICP-MS | Conformity |
| Mercury (Hg) | ≤ 0.1 ppm | ICP-MS | Conformity |
| TPC | ≤ 1,000 CFU/g | Plate Count | Conformity |
| Yeast & Mold | ≤ 100 CFU/g | Plate Count | Conformity |
| E. coli | Negative/25g | USP <62> | Conformity |
| Salmonella | Negative/25g | USP <62> | Conformity |
| Shelf Life | Please refer to batch-specific COA for exact expiry date. | ||
| Package | 1kg/foil bag or 25kg/drum; nitrogen flushed, light-protected. | ||
| Storage | Store cool, dry, dark, sealed below 25°C. | ||
FUNCTIONAL ROLES
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
1. Naturally Occurring Polyamine
Widely distributed in wheat germ, soybeans, mushrooms, and aged cheese. Its dietary presence and endogenous production within cells make it a subject of growing nutritional research interest.
2. Cellular Maintenance and Renewal
Studied for its role in autophagy — the body's natural mechanism for clearing damaged cellular components. Supports products positioned around cellular health and metabolic maintenance.
3. Whole-Food Nutritional Heritage
Abundant in wheat germ — a nutrient-dense component of the wheat kernel valued in whole-food nutrition. Provides an authentic, recognizable origin story for plant-forward supplement lines.
4. Polyamine Matrix Support
Serves as a foundational polyamine ingredient alongside CoQ10, NAD+ precursors, and plant polyphenols in comprehensive cellular wellness complexes.
INDUSTRIAL APPLICATIONS
1. Capsule Manufacturing
50mg–150mg single-active polyamine capsules; compatible with high-speed automatic capsule filling lines in 00–3 capsule sizes.
2. Cellular Wellness Complexes
Co-formulated with CoQ10, PQQ, and NAD+ precursors in comprehensive cellular health and metabolic support blends.
3. Functional Powder Blends
Stick-pack and sachet formats for daily cellular wellness powders; uniform dispersion upon reconstitution with water or juice.
4. OEM / Private Label
Ready-to-encapsulate polyamine ingredient for cellular maintenance, whole-food nutrition, and plant-forward private-label product lines.
OEM & PACKING
OEM
CERTIFICATES
TRANSPORTATION
PACKAGING
TECHNICAL FAQ
Q1: What is the monthly production capacity?
Multi-ton monthly output across the spermidine liposomal product line. Contact our sales team with projected annual requirements for specific capacity allocation and volume-based pricing — both 50% and 70% grades share the same production platform.
Q2: Can you customize the spermidine loading percentage?
Yes. Custom specifications (e.g., 30%, 90%) are available for qualified large-volume OEM projects. Minimum order quantities, lead times, and development fees apply — contact our technical team for feasibility assessment.
Q3: How is spermidine potency verified batch-to-batch?
Every batch undergoes HPLC assay to confirm spermidine loading (target: 50% or 70%), with batch-specific COA provided upon shipment. EE% and DLS particle size are monitored as routine QC parameters. Retention samples are archived for 36 months.