High Absorption Liposomal Apigenin Powder 50% 70% CAS 520-36-5 Bulk Supply OEM Factory Direct
LIPOSOMAL
APIGENIN POWDER
50% | 70%
Liposomal Apigenin Powder delivers 50% or 70% active apigenin (CAS 520-36-5) — a naturally occurring flavonoid from celery and chamomile — encapsulated within a phospholipid bilayer via industrial emulsification and spray-drying. A scalable, dual-strength B2B ingredient for supplement manufacturers targeting the global botanical wellness market.
TECHNICAL SPECIFICATIONS
LIPOSOMAL DELIVERY PRINCIPLE
Apigenin is a lipophilic flavonoid with inherently low aqueous solubility — a well-documented challenge limiting its dispersibility in powder blends and compatibility with aqueous production processes. Without encapsulation, apigenin aggregates and settles unevenly in multi-component formulations.
Our liposomal process addresses this at the industrial level. Apigenin is dissolved in a phospholipid-organic phase, emulsified under controlled high-shear conditions, and spray-dried into a free-flowing powder. Key production benefits: (1) improved water dispersibility via amphiphilic phospholipid carriers; (2) oxidative protection — the bilayer shields the flavonoid from ambient oxygen and light; (3) enhanced blend homogeneity in V-blender and ribbon-blender operations.
KEY ADVANTAGES
1. Dual-Strength Manufacturing
Two standardized loadings — 50% for mainstream pricing and 70% for premium high-potency lines — served from a single production platform. Match your market positioning without changing suppliers.
2. Industrial Batch Consistency
Tight EE% (≥80%) and PDI (≤0.35) monitoring ensures uniform apigenin loading and particle characteristics across every shipment. HPLC assay verification accompanies each batch.
3. Enhanced Process Compatibility
Unlike unencapsulated apigenin requiring organic-solvent pre-dissolution, the liposomal powder disperses directly in aqueous systems under standard mixing — eliminating solvent-handling steps.
4. Multi-Format Versatility
Compatible with capsule filling (00–3 sizes), direct-compression tablets, stick-pack blends, and functional beverage premixes — one ingredient across multiple finished-product SKUs.
MANUFACTURING PROCESS
Raw Material Qualification
Apigenin active (HPLC-verified, ≥98% purity) and plant-derived phospholipids are identity-tested. Each lot screened against specification before production release.
Lipid-Phase Preparation & Emulsification
Apigenin dissolved in phospholipid-organic phase under controlled temperature, then precision high-shear emulsified into aqueous phase — forming stable nano-emulsion with apigenin entrapped within bilayer vesicles.
Spray-Drying
Emulsion spray-dried under optimized temperature profiles, converting liquid liposomal suspension into dry, free-flowing powder while preserving vesicle integrity.
QC Release & CoA
HPLC assay, DLS particle sizing, EE% measurement, heavy metal screening, and microbial testing completed before batch release. Batch-specific CoA issued with every shipment.
CERTIFICATE OF ANALYSIS (COA)
| Product Name | Liposomal Apigenin Powder | Batch No. | CRS20260608 |
| CAS No. | 520-36-5 | Test Date | 2026-06-09 |
| Mfg. Date | 2026-06-08 | Expiry Date | 2026-06-07 |
| Items | Specification | Methods | Results |
| Assay (Apigenin) | 50% / 70% | HPLC | 50.1% / 70.3% |
| Encapsulation Efficiency | ≥ 80% | Centrifugation-UV | 83.5% |
| Particle Size | 80–300nm | DLS | 185nm |
| PDI | ≤ 0.35 | DLS | 0.25 |
| Appearance | Light Yellow to Yellow-Green Powder | Visual | Conformity |
| Loss on Drying | ≤ 5.0% | Gravimetric | 3.8% |
| Heavy Metals (as Pb) | ≤ 10 ppm | ICP-MS | Conformity |
| Arsenic (As) | ≤ 1 ppm | ICP-MS | Conformity |
| Cadmium (Cd) | ≤ 1 ppm | ICP-MS | Conformity |
| Mercury (Hg) | ≤ 0.1 ppm | ICP-MS | Conformity |
| TPC | ≤ 1,000 CFU/g | Plate Count | Conformity |
| Yeast & Mold | ≤ 100 CFU/g | Plate Count | Conformity |
| E. coli | Negative/25g | USP <62> | Conformity |
| Salmonella | Negative/25g | USP <62> | Conformity |
| Shelf Life | Please refer to batch-specific COA for exact expiry date. | ||
| Package | 1kg/foil bag or 25kg/drum; nitrogen flushed, light-protected. | ||
| Storage | Store cool, dry, dark, sealed below 25°C. | ||
FUNCTIONAL ROLES
*This product is not intended to diagnose, treat, cure, or prevent any disease.
1. Antioxidant Flavonoid Support
A naturally occurring flavonoid with recognized antioxidant properties. Contributes to the total antioxidant capacity of multi-flavonoid botanical blends for dietary supplement formulations.
2. Cellular Wellness
Extensively researched for interactions with cellular signaling pathways. Supports wellness formulations positioned around cellular health and metabolic balance in the growing preventative wellness space.
3. Botanical Relaxation Pairing
One of the active flavonoids in chamomile, traditionally associated with relaxation. Serves as a natural companion ingredient alongside L-Theanine and magnesium for evening wellness blends.
4. Multi-Flavonoid Synergy
Complements quercetin, luteolin, and kaempferol in broad-spectrum botanical formulations. Enriches the flavonoid profile of multi-botanical supplement complexes.
INDUSTRIAL APPLICATIONS
1. Capsule Manufacturing
100–250mg single-active botanical flavonoid capsules; compatible with high-speed automatic capsule filling lines in 00–3 capsule sizes.
2. Multi-Botanical Complexes
Co-formulated with quercetin, luteolin, resveratrol, and other plant flavonoids in broad-spectrum antioxidant and wellness blends.
3. Functional Powder Blends
Stick-pack and sachet formats for daily botanical wellness powders; uniform dispersion upon reconstitution with water or juice.
4. OEM / Private Label
Ready-to-encapsulate botanical ingredient for relaxation-support, antioxidant, and multi-flavonoid private-label product lines.
OEM & PACKING
OEM
CERTIFICATES
TRANSPORTATION
PACKAGING
TECHNICAL FAQ
Q1: What is the monthly production capacity?
Multi-ton monthly output across the apigenin liposomal product line. Contact our sales team with projected annual requirements for specific capacity allocation and volume-based pricing — both 50% and 70% grades share the same production platform.
Q2: Can you customize the apigenin loading percentage?
Yes. Custom specifications (e.g., 30%, 90%) are available for qualified large-volume OEM projects. Minimum order quantities, lead times, and development fees apply — contact our technical team for feasibility assessment.
Q3: How is batch-to-batch consistency verified?
Every batch undergoes HPLC assay to confirm apigenin loading (target: 50% or 70%), with batch-specific COA provided upon shipment. EE% and DLS particle size are monitored as routine QC parameters. Retention samples are archived for 36 months.